BRIOTECH INC.

19816 141st PL NE,

Woodinville, WA 98072

United States of America

CERTIFICATIONS
EPA Facility Reg #93108
EPA Product Reg #93108-1

FDA Facility Reg #3012261723

UL CGMP & IS0-22716 Certified

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+1-425-488-4300
info@briotechusa.com

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© 2013-2019  BRIOTECH, ITS LOGOS, LANGUAGE, AND IMAGES ARE TRADEMARKS AND/OR THE COPYRIGHT PROPERTY OF BRIOTECH INC. AND/OR ITS AFFILIATES.

WE MUST BECOME THE CHANGE WE WANT TO SEE IN THE WORLD.

- Mahatma Gandhi

 

INTERNATIONAL CONFERENCE ON PREVENTION & INFECTION CONTROL

SEPTEMBER 13, 2019
 

Geneva, Switzerland | Europe

Dr. Craig Meyers, MS, Ph.D., (Department of Microbiology and Immunology, PennState Cancer Institute) presents an HPV abstract on Brio HOCl™ and its effectiveness against HPV16 and HPV18 at the International Conference on Prevention & Infection Control (ICPIC).

P483 EFFICACY TESTING ON HOCL AS A DISINFECTANT FOR HIGH-RISK HPV

Introduction: High-risk human papillomavirus (HPV 16 & 18) are the causative agents of cervical, anal, and oropharyngeal cancers. Endocavitary ultrasound devices are used in healthcare facilities to examine the cervix, anal canal, and oropharynx; the three areas commonly infected by high-risk HPV. Our previous studies using suspension and carrier tests demonstrated poor efficacy of widely used hospital disinfectants, including GTA (2.4% and 3.4%) and OPA (0.55%) in inactivating high-risk HPV. The potential for iatrogenic transmission in the healthcare environment from inadequate disinfection practices has become an area of contention and discussion. Risk potentials have commonly been based on outdated criteria or inadequately performed studies. There is a need for effective, convenient chemical decontamination measures.

Objectives: To determine the efficacy of exposure to a pure hypochlorous acid preparation (from Briotech Inc.) for inactivation of HPV 16 & 18 using a validated approach based on treatment of high amounts of authentic infectious virus, and well-established methods of replication and testing of high-risk HPVs.

Methods: Infectious stocks of HPV16 and HPV18 were produced, titered, and infectivity-tested as previously described. Both suspension and carrier tests were performed with contact times spanning 15 seconds to 20 minutes. Following contact any remaining HOCl was neutralized using 0.1% Tween 80; 1% peptone; 1% cysteine; 0.5M Tris buffer (pH 7.5). Residual HPV was isolated and measured by our published infectivity methods.

Results: All HOCl treatment times produced >99.99% reduction in infectivity of HPV16 and HPV18, comparable to the efficacy of 0.87% sodium hypochlorite. Exposure of cell fractions enriched by vector expression of L1 and L2 capsid proteins of BPV to HOCl for 30 seconds resulted in rapid aggregation of these and other proteins on SDS PAGE gels.

Conclusion: HOCl proved to be a highly effective disinfectant even with short contact times, using the largest amount of mature infectious HPV16 and HPV18 possible. Rapid changes in capsid proteins may be responsible for the decline in infectivity. HOCl is not toxic on topical application to human skin and mucous membranes, raising the potential for its use not only as a disinfectant, but also in direct applications to human skin, oral and other tissues.

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INTERNATIONAL CONFERENCE ON PREVENTION & INFECTION CONTROL

SEPTEMBER 13, 2019

Geneva, Switzerland | Europe

Dr. Lori Robins, Biochemist, Ph.D. (The University of Washington | Bothell School of STEM) presents the Briotech/UW Prion poster with Dr. Jeff Williams at the International Conference on Prevention & Infection Control (ICPIC).

P487 INACTIVATION OF SCRAPIE PRIONS AND ANTIMICROBIAL PROPERTIES OF HYPOCHLOROUS AND HYPOBROMOUS ACIDS

Introduction: Infectious prion proteins cause neurodegenerative diseases in animals and humans including Mad Cow disease and Creutzfeldt–Jakob disease, respectively. They have been shown to be transmissible via contaminated instruments, tools, and environmental surfaces and require strong and often hazardous conditions (e.g., 20-40% bleach) for disinfection and sterilization. Recently, we showed that hypochlorous acid (HOCl) causes rapid and high-level inactivation of infectious prions. However, hypobromous acid (HOBr) is known to be more potent than HOCl against some microbes including the polio virus. Both of these hypohalous acids are produced in vivo in response to pathogens.

Objectives: We characterized solutions of HOCl and HOBr for direct comparisons against scrapie prions and Escherichia coli, Staphylococcus aureus, and Aspergillus niger.

Methods: HOCl and HOBr were characterized using analytical spectroscopy and spectrophotometry. The hypohalous acids were tested against scrapie prions using the real-time quaking-induced conversion (RT-QuIC) in vitro system.

Results: HOCl at pH 4 showed no detectable changes after storage for months at 22 °C, and had surprising tolerance to heat stress, even at 70 °C. In contrast, HOBr degraded within hours to form mixtures of aqueous bromine species. Scrapie prion inactivation was similar for both HOCl and HOBr. Both hypohalous acids were tested against Escherichia coli, Staphylococcus aureus, and Aspergillus niger and the two differed demonstrably in their efficacies against the various microbes.

Conclusion: Therefore, occasions where shelf life and thermal stability are advantageous, HOCl would be the preferred disinfectant. Alternatively, HOBr tolerance of a wider range of pH conditions and superior efficacy against certain microbes may offer benefits in dealing with other decontamination challenges.

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BRIEFING PAPER OF HYPOCHLOROUS ACID

SEPTEMBER 11, 2019

London, England | Europe

Dr. Jeff Williams, Pathologist, Ph.D., BVSc, MRCVS (Briotech Chief Science Officer) by invitation, presents "Briefing paper on Hypochlorous Acid (HOCl) and its potential applications in international dermatology" with Dr. Lori Robins at The International Foundation Dermatology in London, England.

EPA CLEARANCE

JULY 03, 2019

Woodinville, Washington | USA
Briotech receives EPA Clearance for a multi-purpose surface sanitizer for use on hard non-porous surfaces — an antimicrobial formula and antibacterial sanitizer that prevents odor- causing mold, mildew and algae, and kills harmful bacteria.
EPA Registration No. 93108-1
Company No. 93108

IN THE HEART OF THE EBOLA HOT ZONE

MARCH 18, 2019

Ituri (DRC) | Africa
The initial training seminar, which launched our partnership program, “By Neighbours—For Neighbours”, took place in the heart of the Ebola Hot Zone. Our NGO partner, Purpose Investment Group, together with the Congolese NGO, HOLD – DRC, made this happen!  The By Neighbours—For Neighbours employment program will provide tools to Congolese helping Congolese, and we are beyond thrilled to be involved in addressing groundbreaking health and sanitation solutions with the wonderful people of the DRC.

BRIO AROUND THE WORLD

MARCH 10, 2019

Kivu (DRC) | Africa
Together with our NGO partner, Purpose Investment Group, and with the engagement of the local townspeople, Briotech has begun deployment of product within the North and South provinces of Kivu, Democratic Republic of Congo (DRC); a monumental endeavor that aligns with our philosophy that providing tools, support, education, and employment always promotes success. Local solutions, local engagement, and Briotech.

LAUNCHING DRC EMPLOYMENT PROGRAM

MARCH 03, 2019
 

Democratic Republic of the Congo | DRC
Working with the Congolese NGO, HOLD-DRC, as Briotech’s team-on-the-ground, we’re thrilled to have launched our “By Neighbours—For Neighbours” program into the Democratic Republic of Congo (DRC) with our NGO partner, Purpose Investment Group! The program will soon be employing people in Goma and Kinshasa through bottling, labeling, selling and local distribution of their own Briotech products for use in clinics within the Itaru and Butembo war zones, and in the cities of Goma and Bukavu. Step-by-step, we work toward our Mission to fundamentally and disruptively impact health, healing, and disinfection by revolutionizing the delivery of healthcare and infection control measures through broad adoption and distribution of our company’s pure HOCl products worldwide.

UL REGISTRAR LLC GMP CERTIFICATION

FEBRUARY 21, 2019

Woodinville, Washington | USA
BRIOTECH, Inc.’s facility has been audited by UL Registrar LLC and meets GMP requirements listed in RCP which is uniquely accredited by the National Standard Institute (ANSI) developed in accordance with applicable sections of the FDA’s code of federal regulations.
Certification Number:  i919-319198-1
Certification Number:  a19-319198-1
Certification Number:  m19-319197-1

BEST COMPANY TO WORK FOR

JANUARY 01, 2019

Zippa.com | Woodinville, Washington
BRIOTECH INC. was awarded “Best Performing Companies In Woodinville” and number one in “Best Companies to Work For In Woodinville”.

DISASTER RELIEF DONATION

NOVEMBER 21, 2018

Ventura County | California
BRIOTECH provides Pure Hypochlorous product to Ventura County Animal Services for their efforts during the California wildfires.

 

CONTINUED EFFORT  TOWARDS IMPROVING GLOBAL SANITATION

OCTOBER 16, 2018

The Herald Business Journal | Article
UW Bothell’s continued partnership with BRIOTECH, to improve sanitation in developing regions of the world, leads to a grant from the National Institues of Health (NIH).


Chemistry Professor Causing Stink on Campus - For Good
"Lori Robins was awarded a $155,000 grant from the National Institutes of Health to research how to reduce the foul odor in latrines.“Our goal now is to help people who need it most first," said Robins, an Issaquah native and University of Washington Bothell professor since 2013. "Toilets in developing countries, it’s a huge problem…Our approach is to get rid of the odor and make it more clean by inactivating viruses," said Robins, who has a doctoral degree in bioorganic chemistry. "Viruses that cause diarrhea, for example, can lead to death in developing countries because they don’t have a way to help with the illnesses." The UW Bothell research is a collaboration with Briotech, a small Woodinville company that manufactures hypochlorous acid for skin care.

"One of the things we figured out you can do with this product is control odor," said Briotech science officer Jeff Williams, a retired Michigan professor whose career focused on microbiology and infectious diseases. "It is such a big issue in many people’s lives. I was familiar with it in sanitation and latrines because I’ve worked in India, Africa and South America."

Williams said the university provides the brainpower and technology to study uses for the company’s product…The latrine project started over the summer and has funding for two years."

FULL ARTICLE

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WORKING ON GLOBAL SANITATION

AUGUST 16, 2018

University of Washington Bothell | Article
UW Bothell research continues partnership with BRIOTECH to improve sanitation in developing regions of the world.


UW Bothell Working to Reduce Foul Odor of Latrines, Airing Issue in Global Sanitation
"BOTHELL, Washington — The University of Washington Bothell is helping develop a disinfectant to reduce the foul odor of latrines. More than a superficial air freshener, the goal is a product that would increase the use of pit toilets by making them less offensive. This could improve sanitation in developing regions of the world where defecation in the open air spreads disease.“This could be something that changes the world.” said Robins, a faculty member since 2013 in the Physical Sciences Division of UW Bothell’s School of Science, Technology, Engineering & Mathematics.In work that began this summer, Robins’ research group hopes to show that the chemical spray can combat four stinky compounds in a latrine’s headspace. In addition, they hope to show the aerosol inactivates noroviruses responsible for gastroenteritis, vomiting and diarrhea."

FULL ARTICLE

NIH PRESENTS BRIOTECH AT THE CJD CONFERENCE

JULY 13-15, 2018

CJD Foundation Family Conference |  Washington, DC
NIH research results on BRIO HOCL™ are presented at the annual Creutzfeldt-Jakob Foundation Conference.

Investigation of Prions Inactivation by Reactive Oxygen Species in Vivo.

BRIOTECH PRESENTS AT ICID

MARCH 01, 2018

18th International Congress on Infectious Diseases |  Buenos Aires, Argentina
BRIOTECH is invited by the International Society for Infectious Diseases to present our BRIO HOCLTM Prion Formula during their 18th International Congress on Infectious Diseases (ICID).


This conference has a strong emphasis on the global burden of infectious diseases and we are proud to be attending and providing information on our unique HOCl formulations as an opportunity to challenge major issues with infectious diseases.

BRIOTECH PRESENTS AT THE US FDA

FEBRUARY 06, 2018

US Food and Drug Administration |  Silver Springs, Maryland
By Special Invitation, BRIOTECH Presents at the US FDA


High Level Inactivation of Prions and other Infectious Pathogens with Novel Preparations of Hypohalous Acids.

 

DISASTER RELIEF DONATION

JANUARY 31, 2018

Mae La Refugee Camp | Thai-Burmese Border
BRIOTECH provides Pure Hypochlorous product to the Infinitum Humanitarian Systems (IHS) team, and Dr. Eric Rasmussen’s efforts on the Thai-Burmese Border.

 

FEATURE IN UW BOTHELL MAGAZINE

WINTER, 2017

University of Washington Bothell |  Article

ADVANCING RESEARCH

SEPTEMBER 19, 2017
 

University of Washington Bothell | Article
Chemists at University of Washington Bothell continue the ongoing research of BRIOTECH’s BRIO HOCL™ Prion Formula.

 

Chemistry Researchers Advance Local Company
"University of Washington Bothell research chemists continue to help a small Woodinville company that expects to change the world of sanitizing and disinfecting. A year ago, chemistry students led by Lori Robins, associate professor in the School of STEM, helped the Briotech company prove that its product destroyed prions, the abnormal proteins behind mad cow disease and other neurological diseases. In addition to its (BRIO HOCL PrP Formula™) effectiveness against prions, the solution kills bacteria, fungus and viruses. It can safely sanitize surfaces or medical equipment, and it can protect produce and meat processing. For example, a mist in an apple warehouse might replace toxic methods of killing listeria and E. coli bacteria on fruit."

FULL ARTICLE

BRIOTECH PRESENTS AT ACS

AUGUST 20, 2017

American Chemistry Society Conference | Washington DC
University of Washington, Bothell, presented BRIOTECH’s  breakthroughs in Hypochlorous Acid stability to the world’s largest scientific body at the 254th American Chemistry Society Conference.

"Purity and Stability of an Electrolytically-Generated Hypochlorous Acid Solution"

DISASTER RELIEF DONATION

FEBRUARY 13, 2017
 

Haiti | Dominican Republic
BRIOTECH is proud to be able to support Infinitum Humanitarian Systems (IHS) in their work to bring clean water to the residents of Haiti in the aftermath of Hurricane Matthew.

FEATURE IN THE HERALD BUSINESS JOURNAL

FEBRUARY 01, 2017

The Herald Business Journal | Article
BRIOTECH’s founder and CEO, Dan Terry, creates a disinfectant that has been found to kill the Mad Cow virus and other pathogens.


Woodinville Company's Breakthrough is Surprising
"From Acne to Ebola"

FULL ARTICLE

FEATURE IN HEALTHCARE PURCHASING NEWS

NOVEMBER 16, 2016
 

Healthcare Purchasing News | Article
BRIOTECH Breakthroughs in the inactivation of prion infectivity highlighted for medical instrument sterilization.

Chemical Warfare for Instruments
"It seems like every few months another story on "dirty" surgical instruments hits the media and causes shockwaves throughout the industry. These news reports call attention to what those in the central sterile/sterile processing department (CS/SPD) have long known — that their jobs are critical to delivering safe and effective patient care.

Proteinaceous infectious particles, commonly known as "prions" are pathogens that are composed of ‘unfolded’ proteins containing no DNA. Creutzfeldt-Jakob disease (CJD) and even evidence that suggests Alzheimer’s disease are examples of transmissible spongiform encephalopathies (TSE) which progress rapidly in the brain and are always fatal making them a major concern to healthcare professionals.

"The reprocessing of contaminated instruments that may have been exposed to CJD/TSE in healthcare facilities today need to be assessed. Due to the resilience of prions and potential of the unknown possibility that a patient may have CJD, instrument reprocessing becomes more challenging."

Investigators at the U.S. National Institute of Allergy and Infectious Diseases (NIAID) Rocky Mountain Laboratories, in collaboration with researchers at the University of Washington (UW) Bothell, UW Seattle and the University of Verona (Italy), recently demonstrated the effectiveness of Briotech’s patent- pending unique proprietary formula hypochlorous acid (HOCl) in inactivating prions. HOCl is naturally produced in the body’s cells to aid in ridding it of microbes. Washington-based Briotech has developed BRIO HOCL™, a proprietary disinfectant comprised of HOCl, for use in consumer and professional healthcare settings."

FULL ARTICLE

 

SOCIAL MEDIA SHOUTOUT

OCTOBER 21, 2016

Washington State | USA
Washington State Representative, Congresswoman Suzan DelBene, tweets her BRIOTECH visit.

FEATURE IN INFECTION CONTROL TIPS

OCTOBER 06, 2016
 

Infection Control Tips | Article
BRIOTECH Breakthroughs shared with two million Infection Control Specialists.

Hypochlorous Acid: Harnessing an Innate Response
"BRIO HOCL™  has shown potency in the inactivation of infectious prions at standard temperature and pressure (Hughson et al., 2016). Prions are infectious non-living malformed proteins and responsible for a range of invariably fatal human and animal diseases, including Mad Cow Disease (bovine spongiform encephalopathy), and Cruitzfelt-Jacob Disease in humans. There is evidence developing that Alzheimer’s Disease has an infectious component that is conveyed by prions (Abbott, 2015). As noted in the citation, prions are known to resist all conventional sterilization methods, which require harsh conditions in comparison, yet they were rapidly destroyed on exposure to BRIO HOCL™."

FULL ARTICLE

BREAKTHROUGH AGAINST DEMENTIA

SEPTEMBER 29, 2016

University of Washington Bothell | Article
BRIOTECH’s collaboration with the University of Washington Bothell’s chemistry department.

Students Aid in Breakthrough Against Dementia
"What makes BRIO HOCL™ so promising is that prions are nearly impossible to eliminate by heat, radiation or harsh chemical decontamination. … The efficacy of the Briotech product is particularly interesting in light of research that suggests neurological diseases, including Alzheimer’s, could be spread by prions on medical devices such as probes."

FULL ARTICLE

NIH PRESS RELEASE ON BRIOTECH BREAKTHROUGH

SEPTEMBER 29, 2016
 

National Institutes of Health | Article
BRIOTECH works with the prestigious NIH/RML Laboratories to customize the world’s first cold sterilant to inactivate all prion species.

"Brio HOCl™ eliminated all detectable prion-seeding activity"

Immune System Oxidant could be Key to Inactivating Prions
"A product that mimics the natural oxidative killing action of human immune cells against bacteria, viruses, and fungi also can inactivate prions and other proteins, some of which are thought to be important in Parkinson’s and Alzheimer’s diseases, according to National Institutes of Health (NIH) researchers. Prions are deadly protein-based pathogens that are extremely difficult to inactivate; recommended decontamination treatments often are dangerous to people or damaging to surfaces, such as those on surgical devices. There are reported cases of a prion disease (Creutzfeldt-Jakob disease, or CJD) being transmitted to patients via contaminated surgical equipment.

Scientists at NIH’s National Institute of Allergy and Infectious Diseases (NIAID) first evaluated the product BRIO HOCL™ in laboratory experiments using a prion diagnostic test they developed (RT-QuIC). They then confirmed the results in mice. The scientists determined that BRIO HOCLTM eliminated all detectable prion-seeding activity for CJD, bovine spongiform encephalopathy (BSE, or mad cow disease), chronic wasting disease (a disease primarily found in deer, elk, and moose) and scrapie (a disease of sheep) in brain tissue. They conducted a portion of the study using stainless steel wire as a surrogate for surgical instruments. BRIO HOCL™ had similar effects on two proteins thought to contribute to Parkinson’s disease and Alzheimer’s disease.

The Seattle-area company Briotech, Inc., developed BRIO HOCL™ to remove biofilms – clusters of bacteria – from tubing and other surgical equipment. BRIO HOCL™ is a highly purified formulation of hypochlorous acid, which immune cells produce naturally to kill microbes.
The NIAID researchers now are interested in discovering how hypochlorous acid inactivates prions, and determining whether they can harness that process to treat or prevent prion and other protein-based diseases. They also plan to evaluate whether BRIO HOCL™ can inactivate prions associated with other tissues, fluids, tools, instruments, and environmental surfaces that may be of concern in medicine, biotechnology, agriculture, food production, and wildlife biology.”

FULL ARTICLE

BRIOTECH PUBLISHED IN PLOS PATHOGEN

SEPTEMBER 29, 2016

Public Library of Science | Article
BRIOTECH’s study in conjunction with NIH/RML Laboratories is released in PLOS Pathogen’s: BRIO HOCL™ Safely eliminates all detectable seeding activity of misfolded infectious proteins.

Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid

"We have tested the anti-prion activity of (BRIO HOCL™) that poses no apparent hazard to either users or many surfaces. BRIO HOCL™ can be applied directly to skin and mucous membranes and has been aerosolized to treat entire rooms without apparent deleterious effects."

FULL ARTICLE

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