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BRIOTECH, ITS LOGOS, LANGUAGE, AND IMAGES ARE TRADEMARKS AND/OR THE COPYRIGHT PROPERTY OF BRIOTECH, INC. AND/OR ITS AFFILIATES. © 2013-2018
BRIOTECH, ITS LOGOS, LANGUAGE, AND IMAGES ARE TRADEMARKS AND/OR THE COPYRIGHT PROPERTY OF BRIOTECH, INC. AND/OR ITS AFFILIATES. © 2013-2018
BRIOTECH   is   proud   to   be   able   to   support   Infinitum   Humanitarian   Systems   (IHS)   in   their   work   to   bring   clean   water   to the residents of Haiti in the aftermath of Hurricane Matthew.
IMMUNE SYSTEM OXIDANT COULD BE KEY TO INACTIVATING PRIONS
“We   have   tested   the   anti-prion   activity    of    (BRIO   HOCL TM )    that    poses    no   apparent   hazard   to   either   users   or   many   surfaces.    BRIO   HOCL TM    can    be    applied   directly   to   skin   and   mucous   membranes   and   has   been   aerosolized   to   treat entire rooms without apparent deleterious effects.”
FDA FACILITY REG #3012261723 | EPA #93108
2016
SEPTEMBER 29, 2016
“A product that mimics the natural oxidative killing action of human immune cells against bacteria, viruses, and fungi also can inactivate prions and other proteins, some of which are thought to be important in Parkinson’s and Alzheimer’s diseases, according to National Institutes of Health (NIH) researchers. Prions are deadly protein-based pathogens that are extremely difficult to inactivate; recommended decontamination treatments often are dangerous to people or damaging to surfaces, such as those on surgical devices. There are reported cases of a prion disease (Creutzfeldt-Jakob disease, or CJD) being transmitted to patients via contaminated surgical equipment. Scientists at NIH’s National Institute of Allergy and Infectious Diseases (NIAID) first evaluated the product BRIO HOCL TM  in laboratory experiments using a prion diagnostic test they developed (RT-QuIC). They then confirmed the results in mice. The scientists determined that BRIO HOCL TM  eliminated all detectable prion-seeding activity for CJD, bovine spongiform encephalopathy (BSE, or mad cow disease), chronic wasting disease (a disease primarily found in deer, elk, and moose) and scrapie (a disease of sheep) in brain tissue. They conducted a portion of the study using stainless steel wire as a surrogate for surgical instruments. BRIO HOCL TM  had similar effects on two proteins thought to contribute to Parkinson’s disease and Alzheimer’s disease. The Seattle-area company Briotech, Inc., developed BRIO HOCL TM  to remove biofilms – clusters of bacteria – from tubing and other surgical equipment. BRIO HOCL TM  is a highly purified formulation of hypochlorous acid, which immune cells produce naturally to kill microbes. The NIAID researchers now are interested in discovering how hypochlorous acid inactivates prions, and determining whether they can harness that process to treat or prevent prion and other protein-based diseases. They also plan to evaluate whether BRIO HOCL TM  can inactivate prions associated with other tissues, fluids, tools, instruments, and environmental surfaces that may be of concern in medicine, biotechnology, agriculture, food production, and wildlife biology.”
“BrioHOCl TM  eliminated all detectable prion-seeding activity”
SEPTEMBER 29, 2016
INACTIVATION OF PRIONS AND AMYLOID SEEDS WITH HYPHOCHLOROUS ACID
2017
FEBRUARY 1, 2017
SCIENTIST: WOODINVILLE COMPANY’S BREAKTHROUGH IS SURPRISING
FEBRUARY 13, 2017
FEBRUARY 06, 2018
US Food and Drug Administration  |  Silver Springs, Maryland By Special Invitation, BRIOTECH Presents at the US FDA
WINTER 2017
UW BOTHELL MAGAZINE
Infection Control Tips  | BRIOTECH Breakthroughs shared with two million Infection Control Specialists.
OCTOBER 06, 2016
HYPOCHLOROUS ACID: HARNESSING AN INNATE RESPONSE
“BRIO   HOCL TM      has   shown   potency   in   the   inactivation   of   infectious   prions   at   standard   temperature   and   pressure (Hughson   et   al.,   2016).   Prions   are   infectious   non-living   malformed   proteins   and   responsible   for   a   range   of   invariably fatal   human   and   animal   diseases,   including   Mad   Cow   Disease   (bovine   spongiform   encephalopathy),   and   Cruitzfelt- Jacob    Disease    in    humans.    There    is    evidence    developing    that    Alzheimer’s    Disease    has    an    infectious    component            that   is   conveyed   by   prions   (Abbott,   2015).   As   noted   in   the   citation,   prions   are   known   to   resist   all   conventional sterilization   methods,   which   require   harsh   conditions   in   comparison,   yet   they   were   rapidly   destroyed   on   exposure   to BRIO HOCL TM .”
National    Institutes    of    Health     |    BRIOTECH    works    with    the    prestigious    NIH/RML    Laboratories    to    customize    the world’s first cold sterilant to inactivate all prion species.
Public    Library    of    Science     |    BRIOTECH’s    study    in    conjunction    with    NIH/RML    Laboratories    is    released    in    PLOS Pathogen’s : BRIO HOCL TM  Safely eliminates all detectable seeding activity of misfolded infectious proteins.
Washington State Representative, Congresswoman Suzan DelBene, tweets her BRIOTECH visit.
OCTOBER 21, 2016
The   Herald   Business   Journal    |   BRIOTECH’s   founder   and   CEO,   Dan   Terry,   creates   a   disinfectant   that   has   been found to kill the Mad Cow virus and other pathogens .
American Chemistry Society Conference   |   Washington DC University   of   Washington,   Bothell,   presented   BRIOTECH’s      breakthroughs   in   Hyphochlorous   Acid   stability   to the world’s largest scientific body at the 254th ACS Confrence.
AUGUST 20, 2017
PURITY AND STABILITY  OF AN ELECTROLYTICALLY-GENERATED HYPOCHLOROUS ACID SOLUTION
Healthcare   Purchasing   News    |   BRIOTECH   Breakthroughs   in   the   inactivation   of   prion   infectivity   highlighted for medical instrument sterilization.
NOVEMBER 16, 2016
CHEMICAL WARFARE FOR INSTRUMENTS
“It   seems   like   every   few   months   another   story   on   “dirty”   surgical   instruments   hits   the   media   and   causes   shockwaves throughout   the   industry.   These   news   reports   call   attention   to   what   those   in   the   central   sterile/sterile   processing department (CS/SPD) have long known — that their jobs are critical to delivering safe and effective patient care. Proteinaceous    infectious    particles,    commonly    known    as    “prions”    are    pathogens    that    are    composed    of    ‘unfolded’ proteins   containing   no   DNA.   Creutzfeldt-Jakob   disease   (CJD)   and   even   evidence   that   suggests   Alzheimer’s   disease are   examples   of   transmissible   spongiform   encephalopathies   (TSE)   which   progress   rapidly   in   the   brain   and   are   always fatal making them a major concern to healthcare professionals. “The   reprocessing   of   contaminated   instruments   that   may   have   been   exposed   to   CJD/TSE   in   healthcare   facilities today   need   to   be   assessed.   Due   to   the   resilience   of   prions   and   potential   of   the   unknown   possibility   that   a   patient   may have CJD, instrument reprocessing becomes more challenging.” Investigators   at   the   U.S.   National   Institute   of   Allergy   and   Infectious   Diseases   (NIAID)   Rocky   Mountain   Laboratories, in   collaboration   with   researchers   at   the   University   of   Washington   (UW)   Bothell,   UW   Seattle   and   the   University   of Verona   (Italy),   recently   demonstrated   the   effectiveness   of   Briotech’s   patent-   pending   unique   proprietary   formula hypochlorous   acid   (HOCL)   in   inactivating   prions.   HOCL   is   naturally   produced   in   the   body’s   cells   to   aid   in   ridding   it   of microbes.   Washington-based   Briotech   has   developed   BRIO   HOCL TM ,   a   proprietary   disinfectant   comprised   of   HOCL, for use in consumer and professional healthcare settings.”
HIGH LEVEL INACTIVATION OF PRIONS AND OTHER INFECTIOUS PATHOGENS WITH NOVEL PREPARATIONS OF HYPOHALOUS ACIDS.
“What   makes   BRIO   HOCL TM    so   promising   is   that   prions   are   nearly   impossible   to   eliminate   by   heat,   radiation   or   harsh chemical   decontamination.   …   The   efficacy   of   the   Briotech   product   is   particularly   interesting   in   light   of   research   that suggests neurological diseases, including Alzheimer’s, could be spread by prions on medical devices such as probes.”
SEPTEMBER 29, 2016
STUDENTS AID IN BREAKTHROUGH AGAINST DEMENTIA
University of Washington | Bothell BRIOTECH’s collaboration with the University of Washington Bothell’s chemistry department.
2018
Mae La Refugee Camp |   Thai-Burmese Boarder BRIOTECH   is   happy   to   provide   Pure   Hypochlorous   product   to   the   Infinitum   Humanitarian   Systems   (IHS) team, and Dr. Eric Rasmussen’s efforts on the Thai-Burmese Boarder.
JANUARY 31, 2018
University of Washington   |   Bothell Chemists   at   University   of   Washington   Bothell   continue   the   ongoing   research   of   BRIOTECH’s   BRIO   HOCL TM   Prion Formula.
SEPTEMBER 19, 2017
CHEMISTRY RESEARCHERS ADVANCE LOCAL COMPANY
“University   of   Washington   Bothell   research   chemists   continue   to   help   a   small   Woodinville   company   that   expects   to change the world of sanitizing and disinfecting. A   year   ago,   chemistry   students   led   by   Lori   Robins,   associate   professor   in   the   School   of   STEM,   helped   the   Briotech company    prove    that    its    product    destroyed    prions,    the    abnormal    proteins    behind    mad    cow    disease    and    other neurological diseases. In   addition   to   its   (BRIO   HOCL   PrP   Formula TM )   effectiveness   against   prions,   the   solution   kills   bacteria,   fungus   and viruses.    It    can    safely    sanitize    surfaces    or    medical    equipment,    and    it    can    protect    produce    and    meat    processing.            For example, a mist in an apple warehouse might replace toxic methods of killing listeria and E. coli bacteria on fruit.”
MARCH 01, 2018
18th International Congress on Infectious Diseases  |  Buenos Aires, Argentina BRIOTECH    is    invited    by    the    International    Society    for    Infectious    Diseases    to    present    our    BRIO    HOCL TM Prion Formula during their 18th International Congress on Infectious Diseases (ICID).
This   conference   has   a   strong   emphasis   on   the   global   burden   of   infectious   diseases   and   we   are   proud   to   be attending    and    providing    information    on    our    unique    HOC l     formulations    as    an    opportunity    to    challenge major issues with infectious diseases.  
BRIOTECH, ITS LOGOS, LANGUAGE, AND IMAGES ARE TRADEMARKS AND/OR THE COPYRIGHT PROPERTY OF BRIOTECH, INC. AND/OR ITS AFFILIATES. © 2013-2018
B R I O T E C H  I N  T H E  N E W S
BRIOTECH, ITS LOGOS, LANGUAGE & IMAGES ARE TRADEMARKS & COPYRIGHT PROPERTY OF BRIOTECH, INC. & ITS AFFILIATES. © 2013-2018
CONTACT THE BRIOTECH TEAM
FDA FACILITY REG #3012261723 | EPA #93108
BRIOTECH      is      proud      to      be      able      to      support      Infinitum Humanitarian   Systems   (IHS)   in   their   work   to   bring   clean   water to the residents of Haiti in the aftermath of Hurricane Matthew.
IMMUNE SYSTEM OXIDANT COULD BE KEY TO INACTIVATING PRIONS
“We   have   tested   the   anti-prion   activity    of    (Brio   HOCl TM )    that   poses    no   apparent   hazard   to   either   users   or   many    surfaces.    Brio HOCl TM    can    be    applied   directly   to   skin   and   mucous   membranes and     has     been     aerosolized     to     treat     entire     rooms     without apparent deleterious effects.”
2016
SEPTEMBER 29, 2016
A    product    that    mimics    the    natural    oxidative    killing    action    of human   immune   cells   against   bacteria,   viruses,   and   fungi   also   can inactivate   prions   and   other   proteins,   some   of   which   are   thought to     be     important     in     Parkinson’s     and     Alzheimer’s     diseases, according    to    National    Institutes    of    Health    (NIH)    researchers. Prions   are   deadly   protein-based   pathogens   that   are   extremely difficult        to        inactivate;        recommended        decontamination treatments    often    are    dangerous    to    people    or    damaging    to surfaces,   such   as   those   on   surgical   devices.   There   are   reported cases    of    a    prion    disease    (Creutzfeldt-Jakob    disease,    or    CJD) being      transmitted      to      patients      via      contaminated      surgical equipment. Scientists   at   NIH’s   National   Institute   of   Allergy   and   Infectious Diseases     (NIAID)     first     evaluated     the     product     BrioHOCl     in laboratory     experiments     using     a     prion     diagnostic     test     they developed   (RT-QuIC).   They   then   confirmed   the   results   in   mice. The     scientists     determined     that     BrioHOCl TM      eliminated     all detectable    prion-seeding    activity    for    CJD,    bovine    spongiform encephalopathy    (BSE,    or    mad    cow    disease),    chronic    wasting disease   (a   disease   primarily   found   in   deer,   elk,   and   moose)   and scrapie   (a   disease   of   sheep)   in   brain   tissue.   They   conducted   a portion   of   the   study   using   stainless   steel   wire   as   a   surrogate   for surgical    instruments.    BrioHOCl TM     had    similar    effects    on    two proteins     thought     to     contribute     to     Parkinson’s     disease     and Alzheimer’s disease. The   Seattle-area   company   Briotech,   Inc.,   developed   BrioHOCl to    remove    biofilms    –    clusters    of    bacteria    –    from    tubing    and other     surgical     equipment.     BrioHOCl TM      is     a     highly     purified formulation   of   hypochlorous   acid,   which   immune   cells   produce naturally to kill microbes. The   NIAID   researchers   now   are   interested   in   discovering   how hypochlorous   acid   inactivates   prions,   and   determining   whether they    can    harness    that    process    to    treat    or    prevent    prion    and other     protein-based     diseases.     They     also     plan     to     evaluate whether    BrioHOCl TM     can    inactivate    prions    associated    with other     tissues,     fluids,     tools,     instruments,     and     environmental surfaces    that    may    be    of    concern    in    medicine,    biotechnology, agriculture, food production, and wildlife biology.
“BrioHOCl TM  eliminated all detectable prion-seeding activity”
SEPTEMBER 29, 2016
INACTIVATION OF PRIONS AND AMYLOID SEEDS WITH HYPHOCHLOROUS ACID
FEBRUARY 1, 2017
SCIENTIST: WOODINVILLE COMPANY’S BREAKTHROUGH IS SURPRISING
FEBRUARY 13, 2017
FEBRUARY 06, 2018
US Food and Drug Administration  |  Silver Springs, Maryland By Special Invitation, BRIOTECH Presents at the US FDA
WINTER 2017
UW BOTHELL MAGAZINE
Infection   Control   Tips    |   BRIOTECH   Breakthroughs   shared   with two million Infection Control Specialists .
OCTOBER 06, 2016
HYPOCHLOROUS ACID: HARNESSING AN INNATE RESPONSE
“BRIO    HOCL TM       has    shown    potency    in    the    inactivation    of infectious      prions      at      standard      temperature      and      pressure (Hughson      et      al.,      2016).      Prions      are      infectious      non-living malformed    proteins    and    responsible    for    a    range    of    invariably fatal   human   and   animal   diseases,   including   Mad   Cow   Disease (bovine      spongiform      encephalopathy),      and      Cruitzfelt-Jacob Disease      in      humans.      There      is      evidence      developing      that Alzheimer’s     Disease     has     an     infectious     component     that     is conveyed    by    prions    (Abbott,    2015).    As    noted    in    the    citation, prions      are      known      to      resist      all      conventional      sterilization methods,    which    require    harsh    conditions    in    comparison,    yet they were rapidly destroyed on exposure to Brio HOCL TM  
National    Institutes    of    Health     |    BRIOTECH    works    with    the prestigious   NIH/RML   Laboratories   to   customize   the   world’s   first cold sterilant to inactivate all prion species.
Public    Library    of    Science     |    BRIOTECH’s    study    in    conjunction with    NIH/RML    Laboratories    is    released    in    PLOS    Pathogen’s    : BRIO   HOCL TM     Safely   eliminates   all   detectable   seeding   activity of misfolded infectious proteins.
Washington      State      Representative,      Congresswoman      Suzan DelBene, tweets her BRIOTECH visit.
OCTOBER 21, 2016
The   Herald   Business   Journal    |   BRIOTECH’s   founder   and   CEO, Dan   Terry,   creates   a   disinfectant   that   has   been   found   to   kill   the Mad Cow virus and other pathogens .
American Chemistry Society Conference   |   Washington DC University     of     Washington,     Bothell,     presented     BRIOTECH’s       breakthroughs    in    Hyphochlorous    Acid    stability    to    the    world’s largest scientific body at the 254th ACS Confrence.
AUGUST 20, 2017
PURITY AND STABILITY  OF AN ELECTROLYTICALLY- GENERATED HYPOCHLOROUS ACID SOLUTION
Healthcare    Purchasing    News     |    BRIOTECH    Breakthroughs    in the    inactivation    of    prion    infectivity    highlighted    for    medical instrument sterilization.
NOVEMBER 16, 2016
CHEMICAL WARFARE FOR INSTRUMENTS
“It   seems   like   every   few   months   another   story   on   “dirty”   surgical instruments   hits   the   media   and   causes   shockwaves   throughout the   industry.   These   news   reports   call   attention   to   what   those   in the   central   sterile/sterile   processing   department   (CS/SPD)   have long   known   —   that   their   jobs   are   critical   to   delivering   safe   and effective patient care. Proteinaceous   infectious   particles,   commonly   known   as   “prions” are     pathogens     that     are     composed     of     ‘unfolded’     proteins containing   no   DNA.   Creutzfeldt-Jakob   disease   (CJD)   and   even evidence    that    suggests    Alzheimer’s    disease    are    examples    of transmissible       spongiform       encephalopathies       (TSE)       which progress   rapidly   in   the   brain   and   are   always   fatal   making   them   a major concern to healthcare professionals. “The   reprocessing   of   contaminated   instruments   that   may   have been   exposed   to   CJD/TSE   in   healthcare   facilities   today   need   to be   assessed.   Due   to   the   resilience   of   prions   and   potential   of   the unknown    possibility    that    a    patient    may    have    CJD,    instrument reprocessing becomes more challenging.” Investigators     at     the     U.S.     National     Institute     of     Allergy     and Infectious    Diseases    (NIAID)    Rocky    Mountain    Laboratories,    in collaboration   with   researchers   at   the   University   of   Washington (UW)   Bothell,   UW   Seattle   and   the   University   of   Verona   (Italy), recently    demonstrated    the    effectiveness    of    Briotech’s    patent- pending   unique   proprietary   formula   hypochlorous   acid   (HOCL) in    inactivating    prions.10    HOCL    is    naturally    produced    in    the body’s   cells   to   aid   in   ridding   it   of   microbes.   Washington-based Briotech    has    developed    BrioHOCl,    a    proprietary    disinfectant comprised    of    HOCL,    for    use    in    consumer    and    professional healthcare settings.”
HIGH LEVEL INACTIVATION OF PRIONS AND OTHER INFECTIOUS PATHOGENS WITH NOVEL PREPARATIONS OF HYPOHALOUS ACIDS.
“What   makes   BrioHOCl TM    so   promising   is   that   prions   are   nearly impossible    to    eliminate    by    heat,    radiation    or    harsh    chemical decontamination.    …    The    efficacy    of    the    Briotech    product    is particularly     interesting     in     light     of     research     that     suggests neurological   diseases,   including   Alzheimer’s,   could   be   spread   by prions on medical devices such as probes.”
SEPTEMBER 29, 2016
STUDENTS AID IN BREAKTHROUGH AGAINST DEMENTIA
University of Washington   | Bothell BRIOTECH’s   collaboration   with   the   University   of   Washington Bothell’s chemistry department.
Mae La Refugee Camp |   Thai-Burmese Boarder BRIOTECH   is   happy   to   provide   Pure   Hypochlorous   product   to the    Infinitum    Humanitarian    Systems    (IHS)    team,    and    Dr.    Eric Rasmussen’s efforts on the Thai-Burmese Boarder.
JANUARY 31, 2018
2018
2017
University of Washington   |   Bothell Chemists    at    University    of    Washington    Bothell    continue    the ongoing research of BRIOTECH’s BRIO HOCL TM  Prion Formula.
SEPTEMBER 19, 2017
CHEMISTRY RESEARCHERS ADVANCE LOCAL COMPANY
“University   of   Washington   Bothell   research   chemists   continue to   help   a   small   Woodinville   company   that   expects   to   change   the world of sanitizing and disinfecting. A    year    ago,    chemistry    students    led    by    Lori    Robins,    associate professor   in   the   School   of   STEM,   helped   the   Briotech   company prove   that   its   product   destroyed   prions,   the   abnormal   proteins behind mad cow disease and other neurological diseases. In    addition    to    its    (BRIO    HOCL    PrP    Formula TM )    effectiveness against   prions,   the   solution   kills   bacteria,   fungus   and   viruses.   It can    safely    sanitize    surfaces    or    medical    equipment,    and    it    can protect   produce   and   meat   processing.   For   example,   a   mist   in   an apple   warehouse   might   replace   toxic   methods   of   killing   listeria and E. coli bacteria on fruit.”
MARCH 01, 2018
18th   International   Congress   on   Infectious   Diseases    |      Buenos Aires, Argentina BRIOTECH   is   invited   by   the   International   Society   for   Infectious Diseases   to   present   our   BRIO   HOCL TM Prion   Formula   during their 18th International Congress on Infectious Diseases (ICID).
This   conference   has   a   strong   emphasis   on   the   global   burden   of infectious    diseases    and    we    are    proud    to    be    attending    and providing   information   on   our   unique   HOC l    formulations   as   an opportunity to challenge major issues with infectious diseases.